Weight Loss Drugs & Fertility:What You Need To Know

With growing awareness of how weight can affect fertility, many people are asking: Can weight loss drugs help with conception?

Medications like Ozempic (Semaglutide) and Mounjaro (Tirzepatide) have been making waves in recent years - not just for managing Type 2 Diabetes but also for their potential role in weight loss. 

At Flinders Fertility, we stay at the forefront of emerging research and treatments to help our patients achieve the best possible outcomes. Here’s what you need to know about weight loss medications and their impact on fertility.

The link between weight and fertility

Weight plays a significant role in reproductive health. Being overweight or underweight can disrupt hormone levels, affect ovulation, and lower the chances of conception. Conditions like Polycystic Ovary Syndrome (PCOS), which is commonly associated with insulin resistance and weight gain, can make it even more challenging to conceive.

Recent studies suggest that losing even a small percentage of body weight can improve ovulation and fertility outcomes in some individuals. However, how that weight is lost—whether through lifestyle changes, medication, or surgery—matters.

What about Ozempic?

Ozempic belongs to a group of medications called GLP-1 receptor agonists, which help regulate blood sugar and reduce appetite. While it’s approved in Australia for managing diabetes, it’s not currently approved by the TGA for weight loss. However, some doctors prescribe it “off-label” for this purpose.

Weight Loss Medications Available in Australia

If you’re considering medication to help with weight loss, there are TGA-approved options available on private prescription:

• Wegovy (Semaglutide)
• Saxenda (Liraglutide)
• Mounjaro (Tirzepatide)

What does the Research say?

• Studies indicate that weight loss with GLP-1 medications can improve metabolic health and potentially enhance fertility in certain patients, particularly those with PCOS.
• Some research suggests that weight reduction from GLP-1 agonists can lower inflammation, balance hormones, and improve egg quality.
• However, there is limited fertility-specific research on them, and they are not yet approved for use as a fertility treatment in itself.

Why aren’t all fertility specialists prescribing these drugs?

Despite the promising data, GLP-1 agonists are not yet a routine first-line treatment for fertility patients as there isn’t yet enough fertility-specific research to say it’s a go-to treatment for conception. More studies are needed to understand its long-term effects on pregnancy and reproductive health.

Should you consider weight loss meds for fertility?

While weight loss can positively impact fertility, it’s important to approach it in a way that’s safe and effective for your circumstances. At Flinders Fertility, we encourage patients to:

1. Discuss options with their GP or fertility specialist to determine if medication is appropriate then seek a referral from a GP.
2. Focus on sustainable lifestyle changes, including balanced nutrition and exercise.
3. If you are already taking GLP-1 medications, they should be stopped at least two months before trying to conceive

Final thoughts

Weight loss can improve fertility, but there’s no one-size-fits-all approach. If you’re exploring options, discuss the potential benefits and risks with your doctor.