Platelet-Rich Plasma (PRP) has become a topic of growing interest in fertility care, particularly for patients who are exploring new ways to support ovarian function or improve endometrial receptivity. While PRP is still considered experimental in Australia, early studies suggest it may offer benefits for certain individuals when used carefully and selectively. If you are looking for a clear, patient-friendly explanation of how PRP works and who might benefit from it, this guide will walk you through the essential information.
PRP stands for Platelet-Rich Plasma, a concentrated preparation of your own blood containing platelets and growth factors known to support tissue repair and cellular activity. The process begins with a simple blood draw, usually between 20–60 mL. This sample is then spun in a centrifuge to separate the platelet-rich layer, which can be used in two different reproductive procedures:
Ovarian PRP, where PRP is injected into the ovaries, and
Intrauterine PRP, where PRP is infused into the uterine cavity.
Because PRP comes from your own blood, there is no risk of allergic reaction, and the preparation is used immediately after it is processed
Ovarian PRP (sometimes called "ovarian rejuvenation") is typically performed during an IVF egg collection. The PRP is injected into the ovarian tissue using the same sedation and ultrasound-guided approach already in place for egg retrieval. This means the procedure doesn’t require additional anaesthesia or recovery time beyond what is already planned for your IVF cycle.
Some early research suggests that Ovarian PRP may stimulate follicular activity in people with low ovarian reserve, potentially supporting more eggs in a subsequent cycle. However, results vary, and high-quality research is still limited. PRP is never offered as a replacement for evidence-based fertility treatment but may be considered as an adjunct.
Intrauterine PRP is a quick and straightforward clinic procedure. A soft catheter is passed through the cervix, and PRP is gently infused into the uterine cavity. Many patients find the experience similar to an embryo transfer, with minimal discomfort and no need for sedation.
This approach may be considered for people who have difficulty developing a sufficiently thick endometrium, even after standard treatments. Some studies suggest that PRP can support endometrial tissue and may help improve implantation rates in selected cases.
After either form of PRP, it’s normal to experience mild cramping or spotting for 24–48 hours. Most people feel comfortable resuming normal activities soon after, although it is best to avoid strenuous exercise, intercourse, and tampons for two days. This gives the tissues time to settle following the procedure.
Serious complications are rare, particularly because PRP uses your own biological material.
PRP has gained attention because of its potential to support ovarian activity or help the uterine lining grow. Some of the possible benefits include:
improved follicular activity or egg numbers in select patients with low ovarian reserve
increased endometrial thickness
potential improvement in implantation outcomes
Yet PRP remains experimental, meaning the scientific community is still working to understand exactly who benefits most and under what conditions. It is not a guaranteed treatment, and it may not be suitable for everyone. Your doctor will review your fertility history and advise whether PRP is worth considering as part of your care.
Most risks associated with PRP are mild and self-limiting, such as cramping, spotting, or bruising where the blood was drawn. Infection and minor bleeding are uncommon, and more serious complications—such as ovarian injury—are extremely rare. Long-term safety data is still developing, which is why careful counselling and selection are essential.
PRP may be an option for people who have:
low ovarian reserve
ongoing difficulty achieving adequate endometrial thickness
previous IVF or embryo transfer cycles that were unsuccessful
Your clinician will always discuss standard alternatives, including IVF/ICSI optimisation, donor options, or other emerging therapies, so that you can make an informed decision.
If you are wondering whether PRP may support your fertility goals, the best next step is to speak with your doctor. They can help you understand whether PRP aligns with your personal medical circumstances and guide you through the evidence in a clear and supportive way.
The University of Melbourne has an excellent resource to help you evaluate whether PRP (and other IVF add-ons) may be suitable for you.